WebApr 14, 2024 · Salt-inducible kinase 1 (SIK1), an AMPK-related kinase, regulates energy response-related physiopathologic processes, such as gluconeogenesis and lipid metabolism ().Recently, SIK1, not AMPK, has been increasingly identified as a major player in tumor suppressor liver kinase 1 (LKB1)-deficient NSCLC ().However, the precise roles and … WebApr 19, 2011 · The phosphorylation status of Thr308 and Ser473 was compared with that of three separate Akt substrates – PRAS40, TSC2 and TBC1D4 – in fresh frozen samples of …
Phosphorylation of AKT and ERK1/2 and mutations of PIK3CA
WebMay 5, 2024 · Interestingly, Akt1 is activated by phosphorylation at two key regulatory sites thr308 and ser473. Active Akt1 phosphorylates many downstream cell targets in the cytoplasm and nucleus. Akt1 is for phosphorylating proteins that regulate cell survival and apoptosis. Importantly, Akt1 is hyperphosphorylated and hyperactive in >50% of human … WebNov 6, 2003 · To determine whether the difference in Akt phosphorylation on Ser473, but not on Thr308, observed among cell lines is a cell-specific phenomenon or due to other factors, which possibly ... r.l. stine books newest first
Full article: AKT phosphorylation sites of Ser473 and Thr308 …
WebI am a highly motivated, innovative researcher with expertise on multidisciplinary research including biochemistry, molecular biology, and food and nutritional science. Currently, I am working as a postdoctoral researcher in Biochemistry from Western University. In my current and previous roles in the academia, I have worked on multiple projects, came up with new … WebImmunoprecipitation of phospho-Akt (Thr308) from Jurkat cell extracts using Rabbit (DA1E) mAb IgG XP ® Isotype Control #3900 (lane 2) or Phospho-Akt (Thr308) (D25E6) XP ® Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using Phospho-Akt (Thr308) (D25E6) XP ® Rabbit mAb. Show Less Show More WebDetect and quantitate phospho-AKT 1/2/3 (Thr308) in cell lysates using simple LANCE Ultra TR-FRET assays. We are now two standalone organizations Life Sciences & Diagnostics and Analytical & Enterprise Solutions. Learn More. smtp test software