WebMar 5, 2024 · factor 4 alpha (HNF4A) antisense RNA 1 (HNF4A-AS1), an . antisense lncRNA . of. HNF4A, was. found to be a negative regulator. of. the. basal and rifampicin (RIF)-induced. expression of . nuclear receptors and downstream CYPs. In . Huh7 cells, knockdown of HNF4A-AS1 . resulted. in. elevated expression of . HNF4A, pregnane X receptor (PXR), and … WebPBMs were used to examine the DNA binding specificity of human HNF4a2 (referred to as HNF4a), RXRa and COUPTF2. They bound 1371, 1285 and 1530 unique DNA sequences, …
The correlation between HNF4a and other clock genes in BLCA, …
WebApr 7, 2024 · Maturity-onset diabetes of the young (MODY) is an inherited form of diabetes caused by a mutation in a single gene. The frequency of mutation carriers for HNF4A-MODY has been reported to be 1.2% ().Our group has previously published on the successful use of glucagon-like peptide 1 receptor agonist (GLP-1 RA) therapy in three consecutive … WebCell Reports Article RORa Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis Yong-Hyun Han,1 Hyeon-Ji Kim,1 Hyelin Na,1 Min-Woo Nam,1 Ju-Yeon Kim,1 Jun-Seok Kim,4 Seung-Hoi Koo,4 and Mi-Ock Lee1,2,3,5,* 1College of Pharmacy 2Bio-MAX Institute 3Research Institute of … gray concrete driveway
Ser100-Phosphorylated RORα Orchestrates CAR and HNF4α to …
WebThe HNF4A gene provides instructions for making a protein called hepatocyte nuclear factor-4 alpha (HNF-4α). This protein plays an important role in the function of certain … WebThe HNF4A gene uses two separate promoters P1 and P2, with P1 products predominant in adult liver, whereas P2 products prevalent in fetal liver, pancreas, and liver/colon cancer. … WebApr 17, 2024 · Previously, it was found that nuclear receptors HNF4a and RORa form as complexes binding to the SULT1E1 enhancer (−943/−922 bp) to activate gene expression … chocolate stores in buffalo ny