Peroxisome proliferator-activated receptor-α

Author: jgys

August undefined, 2024

WebThe peroxisomal β-oxidation system consists of (a) a classical peroxisome proliferator - inducible pathway capable of catalyzing straight-chain acyl-CoAs by fatty acyl-CoA oxidase, L-bifunctional protein, and thiolase, and (b) a second noninducible pathway catalyzing the oxidation of 2-methyl-branched fatty acyl-CoAs by branched-chain acyl-CoA … WebPeroxisome proliferator-activated receptors (PPAR) are nuclear transcription factors that modulate gene expression. They are designated as PPAR alpha (α), PPAR beta (β) also known as PPAR delta (δ), and PPAR gamma (γ) [1 ]. The thiazolidinediones (glitazones) are PPARγ agonists and are covered in a separate monograph.

The UDP-glucuronosyltransferase 1A9 Enzyme Is a Peroxisome Proliferator …

WebOct 13, 2003 · Peroxisome proliferator–activated receptor-α (PPAR-α) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. PPAR-α increases gene … WebThe protein levels of PPAR-γ, α-smooth muscle actin (α-SMA) and type I collagen expression were evaluated by the Western blotting method. Results In vitro studies revealed that expression of PPAR-γ inhibited expression of α-SMA and type I collagen in activated HSCs (P<0.01) as well as HSC proliferation (P<0.01). construction mattress memory foam bob

Activation of peroxisome proliferator-activated receptor …

WebMar 9, 2024 · Peroxisome proliferator-activated receptor- γ coactivator (PGC)-1 α is a transcriptional coactivator described as a master regulator of mitochondrial biogenesis … WebPeroxisome proliferator-activated receptor-α (PPARα) is a nuclear hormone receptor which regulates the oxidation and transport of fatty acids. Upon activation it binds as a … WebApr 5, 2011 · Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is a transcriptional coactivator able to up-regulate mitochondrial biogenesis, respiratory capacity, oxidative phosphorylation, and fatty acid β-oxidation with the final aim of providing a more efficient pathway for aerobic energy production. construction media titles

Cardiomyocyte peroxisome proliferator-activated receptor α is

Peroxisome proliferator-activated receptor - Wikipedia

Three types of PPARs have been identified: alpha, gamma, and delta (beta): • α (alpha) - expressed in liver, kidney, heart, muscle, adipose tissue, and others • β/δ (beta/delta) - expressed in many tissues, especially in brain, adipose tissue, and skin • γ (gamma) - although transcribed by the same gene, this PPAR, by way of alternative splicing, is expressed in three forms: WebMay 27, 2024 · The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that promote ligand-dependent transcription of target genes that regulate energy production, lipid metabolism, and inflammation. The PPAR superfamily comprises three subtypes, PPARα, PPARγ, and PPARβ/δ, with differential tissue … education and awareness creationPeroxisome proliferator-activated receptor alpha (PPAR-α), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is encoded by the PPARA gene. Together with peroxisome proliferator-activated receptor delta … See more PPAR-α is primarily activated through ligand binding. Endogenous ligands include fatty acids such as arachidonic acid as well as other polyunsaturated fatty acids and various fatty acid-derived compounds such as … See more Expression of PPAR-α is highest in tissues that oxidize fatty acids at a rapid rate. In rodents, highest mRNA expression levels of PPAR-alpha are found in liver and brown adipose tissue, followed by heart and kidney. Lower PPAR-alpha expression levels are found in … See more PPAR-α is the pharmaceutical target of fibrates, a class of drugs used in the treatment of dyslipidemia. Fibrates effectively lower serum triglycerides and raises serum HDL-cholesterol levels. Although clinical benefits of fibrate treatment have been … See more PPAR-α has been shown to interact with: • AIP, • EP300 • HSP90AA1, • NCOA1, and • NCOR1. See more PPAR-α is a transcription factor regulated by free fatty acids, and is a major regulator of lipid metabolism in the liver. PPAR-alpha is activated under conditions of energy deprivation … See more Studies using mice lacking functional PPAR-alpha indicate that PPAR-α is essential for induction of peroxisome proliferation by a diverse set of synthetic compounds referred to as peroxisome proliferators. Mice lacking PPAR-alpha also have an … See more PPAR-α governs biological processes by altering the expression of a large number of target genes. Accordingly, the functional role of PPAR-alpha is directly related to the … See more education and assimilation

"WebPeroxisome-proliferator activator receptors (PPARs) form a family of nuclear hormone-activated receptors and transcription factors that regulates the function and expression … " - Peroxisome proliferator-activated receptor-α

The UDP-glucuronosyltransferase 1A9 Enzyme Is a Peroxisome Proliferator …

Activation of peroxisome proliferator-activated receptor …

Peroxisome proliferator-activated receptor-α

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