Daptomycin and renal failure
WebIn a cohort of patients with severe renal dysfunction treated with daptomycin 7.5 mg/kg or greater, significant CK elevation on daptomycin therapy was infrequently observed. Future research should confirm these findings, with special consideration for higher mg/kg dosages and/or obese populations. WebApr 2, 2024 · Vancomycin (VCM) and daptomycin (DAP) are standard therapies for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, despite concerns regarding clinical utility and growing resistance. Linezolid (LZD) affords superior tissue penetration to VCM or DAP and has been successfully used as salvage therapy for persistent MRSA …
Daptomycin and renal failure
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WebSummary: Acute kidney failure is found among people who take Daptomycin, especially for people who are male, 60+ old, have been taking the drug for < 1 month. The phase IV … WebMar 15, 2013 · Eradication was defined as elimination of the organism while on high-dose daptomycin, and persistence was defined as failure to eradicate the organism at the end of high-dose daptomycin therapy (21, 25). Organism identification, local susceptibility data, and baseline blood isolates were collected, if available, and evaluated for extended ...
WebTemporarily discontinue simvastatin in patients experiencing an acute or serious condition at high risk of developing renal failure secondary to rhabdomyolysis. Inform patients of the risk of myopathy and rhabdomyolysis when starting or increasing simvastatin dosage. ... Both simvastatin and daptomycin can cause myopathy and rhabdomyolysis when ... WebAlthough daptomycin is a well-tolerated antibacterial agent, clinicians should consider periodic monitoring of liver function and renal function tests to identify potential adverse …
WebJul 5, 2024 · Thrombotic thrombocytopenic purpura (TTP), a condition manifested by fever, renal failure, thrombocytopenia, microangiopathic hemolytic anemia with or without neurologic manifestations A hemolytic … WebMar 18, 2014 · There was no significant difference in the efficacy of daptomycin in patients with impaired renal function in methicillin-resistant Staphylococcus aureus bloodstream infection compared with vancomycin using a propensity …
Web• In patients with renal failure, the time to achievement of steady-state is increased for renally-eliminated agents. Additionally, patients on CRRT frequently have an increased …
WebApr 16, 2024 · Daptomycin dosing for each individual was calculated as milligrams per kilogram per dose, based on ABW, per institution guidelines (guidelines also recommend renal dosing for CrCl <30 mL/min, weekly CPK monitoring, and … ipic maverickWebJan 1, 2024 · To our knowledge, there have been no reported cases of daptomycin-induced hepatotoxicity in the absence of hyperbilirubinemia, renal failure and CK abnormalities. Six other case reports of daptomycin-induced hepatotoxicity have been published on patients without pre-existing liver disease [6, [8], [9], [10], [11], [12]]. orangesonline.comWebDaptomycin causing renal failure and hepatic injury, concurrently with rhabdomyolysis, is an even rarer entity. We performed a literature search in PubMed … orangesoft incWebMay 23, 2024 · Several AKI risk factors have been identified including a chronic pathology of the patient such as kidney failure or diabetes, acute kidney injury related to … orangestorm electronicsWebMar 7, 2024 · INTRODUCTION. Daptomycin is a lipopeptide antimicrobial with activity against gram-positive organisms, including antimicrobial-resistant pathogens such … orangesport onlineWebOct 26, 2007 · Daptomycin is removed by haemodialysis; ∼15% of an administered dose is eliminated in a 4 h haemodialysis session and ∼11% after 48 h of CAPD. 2 Therefore, in patients with reduced renal function, including those receiving haemodialysis and peritoneal dialysis, the recommended dose interval is 48 h. 2 ipic mckinney txWebThe serum half-life of the drug is 8–9 hours. 9 Daptomycin is renally excreted, and its systemic clearance in healthy adults is 0.011 L/kg/h. 10 Dosing must be adjusted for adult subjects who have impaired creatinine clearance. 11,12 In patients with chronic kidney disease stage 4 (creatinine clearance <30 mL/min) and in subjects undergoing ... orangespotted sunfish family