WebMembers of the copper uptake transporter (CTR) family from yeast, plants, and mammals including human are required for cellular uptake of the essential metal copper. Based on biochemical data, CTRs have three … WebJul 16, 2013 · copper transporter (CTR), host defence, innate immunity, monocyte, Toll-like receptor, zinc transporter INTRODUCTION The immune system requires essential micronutrients and trace elements such as iron, zinc, …

SLC31 (CTR) family of copper transporters in health and disease

Webthe SLC31 or Ctr family of proteins mediates cellular copper uptake. These high-affinity copper transporters exist in all eukaryotes and their discovery has provided new insights into how cells acquire and regulate this essential nutrient. The following is a brief overview of the SLC31 copper transporter family with a focus on the human hCtr1 ... WebCopper Transporter 1 (CTR1) is the high-affinity copper importer found in all eukaryotic organisms. The copper transporter family primarily comprises ~ six members (CTR1-6) and the related members share high sequence homology with CTR. However, with the exception of CTR1, not all six CTRs are present in every organism. crystal needles naruto

Molecular characterization of the COPT/Ctr-type copper transporter ...

WebApr 1, 2013 · CTR-mediated copper uptake in organs and tissues Several lines of evidence confirmed that the CTR family of proteins plays a major role in copper translocation across the cellular membranes into the cytoplasm in eukaryotes. Slc31a1 gene knockout mice have revealed the important roles for CTR1 in mouse embryo development. WebJun 30, 2024 · Among various heavy metals, copper (Cu) is both essential and toxic to plants depending on the concentration and complex homeostatic networks. The Cu transporter family (COPT) plays important roles in Cu homeostasis, including absorption, transportation, and growth in plants; however, this gene family is still poorly understood … Websimilarity to bacterial copper-binding motifs and are predicted to face the extracytoplasmicregion (Fox and Guerinot, 1998). However, the expression and func-tion of COPT1 or other potential copper transporters in plants remain mostly unknown. In this work, we have identified and analyzed five members of the Ctr copper transporter … crystal needle